Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.

摘要: Serotonin and its receptors (HTRs) play critical roles in brain development the regulation of cognition, mood, anxiety. HTRs are highly expressed human prefrontal cortex exert control over excitability. The serotonin system is a key treatment target for several psychiatric disorders; however, effectiveness these drugs varies according to age. Despite strong evidence developmental changes Htrs rodents, HTR expression has not been examined. Using postmortem tissue from across postnatal life, we investigated with distinct inhibitory (HTR1A, HTR5A) excitatory (HTR2A, HTR2C, HTR4, HTR6) effects on cortical neurons, including two which appear be greater degree interneurons cerebral (HTR2C, HTR6). We found patterns each six HTRs, profound occurring early also into adulthood. However, collective look at terms their likely neurophysiological major cellular localization leads model that suggests individual may perturb an overall balance between effects. Examining understanding healthy appreciate how abnormal create window vulnerability emergence illness.