Pirt, a TRPV1 Modulator, Is Required for Histamine-Dependent and -Independent Itch
作者： Kush N. Patel , Qin Liu , Sonya Meeker , Bradley J. Undem , Xinzhong Dong
DOI: 10.1371/JOURNAL.PONE.0020559
关键词:
摘要: Itch, or pruritus, is an important clinical problem whose molecular basis has yet to be understood. Recent work begun identify genes that contribute detecting itch at the level. Here we show Pirt, known play a vital part in sensing pain through modulation of transient receptor potential vanilloid 1 (TRPV1) channel, also necessary for proper sensation. Pirt−/− mice exhibit deficits cellular and behavioral responses various itch-inducing compounds, pruritogens. Pirt contributes both histaminergic nonhistaminergic and, crucially, involved forms are TRPV1-dependent -independent. Our findings demonstrate function extends beyond nociception via TRPV1 regulation its role as critical component several signaling pathways.
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