Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells
作者： Bingxiu Xiao , Junming Guo , Donghai Liu , Shun Zhang
DOI: 10.1016/J.ORALONCOLOGY.2006.11.002
关键词:
摘要: Aloe-emodin is a natural anthraquinone compound from the root and rhizome of Rheum palmatum. In this study, KB cells were treated with 2.5, 5, 10, 20, 40 microM aloe-emodin for 1 to 5 days. The results showed that inhibited cancer in dose-dependent manner. Treatment at 10 resulted cell cycle arrest G2/M phase. alkaline phosphatase (ALP) activity increased upon treatment when compared controls. This one first studies focus on expression ALP human oral carcinomas aloe-emodin. These indicate has anti-cancer effect cancer, which may lead its use chemotherapy chemopreventment cancer.
elsevier.com
sci-hub.se 参考文章(25)
A J Giaccia, B G Wouters, N C Denko, J M Brown, Loss of p21Waf1/Cip1 Sensitizes Tumors to Radiation by an Apoptosis-independent Mechanism Cancer Research. ,vol. 57, pp. 4703- 4706 ,(1997)
Dongsool Yim, Chapla Agarwal, Rana P Singh, Sookyeon Lee, Rajesh Agarwal, Hyungjoon Chi, A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Research. ,vol. 65, pp. 1035- 1044 ,(2005)
Michael Andreeff, M. Fatih Okcu, Victor Levin, Paul Chiao, Sanbao Ruan, Jiang Ping Ren, Wei Zhang, Overexpressed WAF1/Cip1 Renders Glioblastoma Cells Resistant to Chemotherapy Agents 1,3-Bis(2-chloroethyl)-1-nitrosourea and Cisplatin Cancer Research. ,vol. 58, pp. 1538- 1543 ,(1998)
B. Xiao, J. Guo, Y. Lou, D. Meng, W. Zhao, L. Zhang, C. Yan, D. Wang, Inhibition of growth and increase of alkaline phosphatase activity in cultured human oral cancer cells by all-trans retinoic acid. International Journal of Oral and Maxillofacial Surgery. ,vol. 35, pp. 643- 648 ,(2006) , 10.1016/J.IJOM.2006.01.005
C Didelot, J F Mirjolet, M Barberi-Heyob, C Ramacci, J L Merlin, Radiation could induce p53-independent and cell cycle--unrelated apoptosis in 5-fluorouracil radiosensitized head and neck carcinoma cells. Canadian Journal of Physiology and Pharmacology. ,vol. 80, pp. 638- 643 ,(2002) , 10.1139/Y02-069
S. Mijatovic, D. Maksimovic-Ivanic, J. Radovic, Dj. Miljkovic, Lj. Harhaji, O. Vuckovic, S. Stosic-Grujicic, M. Mostarica Stojkovic, V. Trajkovic, Anti-glioma action of aloe emodin: the role of ERK inhibition. Cellular and Molecular Life Sciences. ,vol. 62, pp. 589- 598 ,(2005) , 10.1007/S00018-005-4425-8
HS Liu, CY Chen, C-H Lee, Y-I Chou, Selective activation of oncogenic Ha-ras-induced apoptosis in NIH/3T3 cells British Journal of Cancer. ,vol. 77, pp. 1777- 1786 ,(1998) , 10.1038/BJC.1998.296
H.C Chen, W.T Hsieh, W.C Chang, J.G Chung, Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. Food and Chemical Toxicology. ,vol. 42, pp. 1251- 1257 ,(2004) , 10.1016/J.FCT.2004.03.002
Shin-Hun Juang, Wen-Yu Pan, Ching-Chuan Kuo, Jing-Ping Liou, Yi-Mei Hung, Li-Tzong Chen, Hsing-Pang Hsieh, Jang-Yang Chang, A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells Biochemical Pharmacology. ,vol. 68, pp. 293- 303 ,(2004) , 10.1016/J.BCP.2004.03.036
H. Eagle, Propagation in a fluid medium of a human epidermoid carcinoma, strain KB. Experimental Biology and Medicine. ,vol. 89, pp. 362- 364 ,(1955) , 10.3181/00379727-89-21811