Epstein–Barr virus-positive T/NK-cell lymphoproliferative disorders

摘要: Epstein–Barr virus, a ubiquitous human herpesvirus, can induce both lytic and latent infections that result in variety of diseases, including lymphoproliferative disorders. The oncogenic potential virus is related to its ability infect transform B lymphocytes into continuously proliferating lymphoblastoid cells. However, has also been implicated the development T/natural killer cell diseases. encodes series products mimic several growth, transcription anti-apoptotic factors, thus usurping control pathways regulate diverse homeostatic cellular functions microenvironment. exact mechanism by which promotes oncogenesis inflammatory lesion remains unclear. virus-associated diseases often have overlapping clinical symptoms as well histologic immunophenotypic features because lymphoid types derive from common precursor. Accurate classification prerequisite for appropriate management. Currently, treatment most less than satisfactory. Novel targeted therapies are strongly required satisfy demands. This review describes our current knowledge genetics, oncogenesis, biology, diagnosis