Beyond Polymaxenolide: Cembrane-Africanane Terpenoids from the Hybrid Soft Coral Sinularia maxima × S. polydactyla

摘要: The effects of natural hybridization on secondary metabolite production and diversification have only recently been studied in plants essentially overlooked marine organisms. Chemical investigation the hybrid soft coral Sinularia maxima × S. polydactyla resulted isolation five new terpenoids, 7E-polymaxenolide (1), 7E-5-epipolymaxenolide (2), polymaxenolides A−C (3−5), possessing a cembrane-africanane skeleton. Their structures were established by detailed analysis NMR MS data. contentious issue defining absolute configuration at stereogenic centers conformationally mobile cembrane macrocyclic ring was addressed joint application electronic circular dichroism X-ray diffraction analyses.