Conithiaquinones A and B, Tetracyclic Cytotoxic Meroterpenes from the Mediterranean Ascidian Aplidium conicum
作者： Marialuisa Menna , Anna Aiello , Filomena D'Aniello , Concetta Imperatore , Paolo Luciano
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摘要: Chemical investigation of the Mediterranean ascidian A. conicum resulted in isolation two new meroterpenes, conithiaquinones A (1) and B (2), addition to previously reported chromenols (3 4) conicaquinones (5 6). The structures were determined by interpretation spectroscopic data, regiochemical stereochemical assignments achieved with aid computational methods, including recently developed DP4 NMR spectral prediction method. Both showed significant effects on growth viability cells, 1 showing interesting cytotoxicity against human breast cancer cells.
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