Cord blood and consecutive chitotriosidase activity: Relationship to prematurity and early prognosis.

摘要: Background The aim of this study was to investigate the relationship between plasma chitotriosidase activity, an inflammatory protein secreted mainly from macrophages, and neonatal morbidity mortality in premature infants. Methods Cord blood activity studied healthy control infants (53 term, group 1; 26 late preterm [33–37 gestational weeks], 2) 35 (≤32 weeks; 3). In 3, consecutive samples at 3 h, 24 h, 72 h, 7 days, 14 days, 36 weeks after conception were also analyzed. Group 3 evaluated for mortality, respiratory treatment bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), intraventricular hemorrhage (IVH) retinopathy prematurity (ROP) necrotizing enterocolitis (NEC). Results Cord positively correlated with gestational age birthweight. SNAPPE-II score 24 h. Consecutive non-significantly higher who died early period. Higher observed mechanically ventilated than treated non-invasive assisted ventilation. BPD, PDA, IVH ROP, but not NEC, related being significant some time points. Conclusion Neonatal stress such as invasive ventilation may create a risk development IVH, ROP by increasing macrophage activation reflected activity. High be associated disease severity mortality.