Duodenal cytochrome b (DCYTB) in iron metabolism: an update on function and regulation.

摘要: Iron and ascorbate are vital cellular constituents in mammalian systems. The bulk-requirement for iron is during erythropoiesis leading to the generation of hemoglobin-containing erythrocytes. Additionally, both required as co-factors numerous metabolic reactions. homeostasis controlled at level uptake, rather than excretion. Accumulating evidence strongly suggests that addition known ability dietary enhance non-heme absorption gut, regulates homeostasis. involvement extends beyond direct chemical reduction by ascorbate. Among other activities, intra-enterocyte appears be involved provision electrons a family trans-membrane redox enzymes, namely those cytochrome b561 class. These hemoproteins oxidize pool on one side membrane order reduce an electron acceptor (e.g., iron) opposite membrane. One member this family, duodenal b (DCYTB), may play important role ascorbate-dependent gut prior uptake ferrous-iron transporters. This review discusses emerging relationship between homeostasis, emergent “IRP1-HIF2α axis”, DCYTB relation metabolism.