Analysis of polymorphism and hepatic expression of duodenal cytochrome b in chronic hepatitis C
作者： Alina Rudnicka , Anna Woziwodzka , Anna Wróblewska , Magda Rybicka , Krzysztof P Bielawski
DOI: 10.1111/JGH.13495
关键词:
摘要: BACKGROUND AND AIM Pathological iron overload is commonly found in chronic hepatitis C (CHC) patients and considered as a negative prognostic factor of the disease. A single nucleotide polymorphism (SNP) rs884409 duodenal cytochrome b gene (CYBRD1) implicated pathogenesis hemochromatosis. In our study we investigated impact CYBRD1 genotype expression on CHC patients. METHODS Liver biopsy specimens whole blood samples from 243 with were included study. Iron deposits hepatocytes, serum markers overload, profile gene-regulators homeostasis analyzed. Genotyping analysis performed. The frequency SNP levels compared between groups without overload. RESULTS variant G was associated elevated levels, increased liver inflammation, oxidative stress. Hepatic Tfr2, Id1, HO-1 genes, ferritin accumulation liver. CONCLUSION These results implicate involvement CHC.
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