The spontaneously hypertensive and Wistar Kyoto rat models of ADHD exhibit sub-regional differences in dopamine release and uptake in the striatum and nucleus accumbens
作者： Erin M. Miller , Francois Pomerleau , Peter Huettl , Vivienne A. Russell , Greg A. Gerhardt
DOI: 10.1016/J.NEUROPHARM.2012.08.020
关键词:
摘要: The most widely used animal model of attention-deficit/hyperactivity disorder (ADHD) is the spontaneously hypertensive rat (SHR/NCrl), which best represents combined subtype (ADHD-C). Recent evidence has revealed that a progenitor strain, Wistar Kyoto from Charles River Laboratories (WKY/NCrl), useful as inattentive (ADHD-PI) and Harlan (WKY/NHsd) Sprague Dawley (SD) have been suggested controls. Dopamine (DA) dysfunction in striatum (Str) nucleus accumbens core (NAc) thought to play significant role pathophysiology ADHD but data obtained with SHR equivocal. Using high-speed chronoamperometric recordings carbon fiber microelectrodes, we found SHR/NCrl displayed decreased KCl-evoked DA release versus WKY/NCrl ADHD-PI dorsal Str. WKY/NHsd control did not differ each other; however, SD released less than Str intermediate had faster uptake ventral NAc both strains, while exhibited control. These results suggest increased surface expression transporters may explain more rapid these rodent models ADHD.
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