Comparison of the validity of the use of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder in males and females.
作者： Daniel W. Bayless , Maria C. Perez , Jill M. Daniel
DOI: 10.1016/J.BBR.2015.02.029
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摘要: Abstract The spontaneously hypertensive rat (SHR) is a commonly used and well-studied rodent model of attention deficit hyperactivity disorder (ADHD). Sex differences in the cognitive symptoms ADHD are reported. However, female SHR much less studied than its male counterpart. goal current study was to assess validity by examining attentional performance, inhibitory control, both rats. Adult control Wistar–Kyoto rats were trained on 5-choice serial reaction time task, self-paced test control. This task requires animals identify location brief light stimulus among five possible locations under several challenging conditions. Analyses percent correct revealed that performance females not significantly different from females, whereas males males. number premature responses made more errors did this decrease present females. activity open field hyperactive increased findings have implications for sex use as
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