The prevalence of asthma appears to be inversely related to the incidence of typhoid and tuberculosis: hypothesis to explain the variation in asthma prevalence around the world.

作者: P.D. Jones , P.G. Gibson , R.L. Henry

DOI: 10.1054/MEHY.1999.0997

关键词:

摘要: Abstract The prevalence of asthma varies widely throughout the world. We now believe that is due to airway inflammation caused by an imbalance T-lymphocytes in airway. atopy drives a predominance Th 2 lymphocytes This paper links inversely tuberculosis and enteric infection. will argue reason we observe such marked variations around world fact developing there survival advantage fetal immune response mature from 1 lymphocyte predominant. A required combat infectious diseases as typhoid tuberculosis. Data World Health Organization confirms these two occur very rarely those communities where high. It may be clean infection-free environment Australia New Zealand responsible for region Oceania having dubious honor highest

参考文章(6)
Patrick G Holt, Peter D Sly, Breaking the nexus between asthma and atopy The Medical Journal of Australia. ,vol. 169, pp. 354- 355 ,(1998) , 10.5694/J.1326-5377.1998.TB126801.X
Gordon J Rennick, Frederick C Jarman, Are children with asthma affected by smog The Medical Journal of Australia. ,vol. 156, pp. 837- 841 ,(1992) , 10.5694/J.1326-5377.1992.TB136995.X
Thomas G. Wegmann, Hui Lin, Larry Guilbert, Tim R. Mosmann, Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunology Today. ,vol. 14, pp. 353- 356 ,(1993) , 10.1016/0167-5699(93)90235-D
Sanjiv Sur, Gerald J. Gleich, Mark C. Swanson, Kathleen R. Bartemes, David H. Broide, Eosinophilic inflammation is associated with elevation of interleukin-5 in the airways of patients with spontaneous symptomatic asthma ☆ ☆☆ ★ ★★ The Journal of Allergy and Clinical Immunology. ,vol. 96, pp. 661- 668 ,(1995) , 10.1016/S0091-6749(95)70265-2