Evaluation of age-dependent response to NMDA receptor antagonism in zebrafish.
作者： Fabiano Peres Menezes , Luiza Wilges Kist , Maurício Reis Bogo , Carla Denise Bonan , Rosane Souza Da Silva
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摘要: Abstract Imbalances in glutamatergic signaling have been proposed as the cause of several neurological disturbances. The use MK-801, an N-methyl-d-aspartate (NMDA) receptor antagonist, to mimic features these disorders is effective both mammals and fish. However, variability subunits comprising NMDA during development alters pharmacokinetic properties leads different responses this drug. Here, we evaluated locomotor response zebrafish MK-801 (1, 5, 20 μM) through (30 days postfertilization [dpf] 2 years [ypf]). subunit gene expression was also analyzed (7 dpf 2 ypf). Zebrafish displayed age-related with a higher at 60 120 dpf. magnitude hyperlocomotion promoted by seems be less powerful for relation rodents. verification levels rec...
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