Chronic treatment with caffeine blunts the hyperlocomotor but not cognitive effects of the N-methyl-d-aspartate receptor antagonist MK-801 in mice
作者： Oscar P. Dall'Igna , Adriana L. da Silva , Marcelo O. Dietrich , Anselmo Hoffmann , Ricardo V. de Oliveira
DOI: 10.1007/S00213-002-1362-1
关键词:
摘要: Rationale Administration of N-methyl-d-aspartate (NMDA) receptor antagonists produce hyperlocomotion and cognitive deficits in rodents. Activation NMDA receptors promotes adenosine release, agonists prevent central effects antagonists. We hypothesized that if require to behavioral effects, mice tolerant the antagonist caffeine would have a diminished response
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