Advances in the neurophysiology of magnocellular neuroendocrine cells.

摘要: Hypothalamic magnocellular neuroendocrine cells have unique electrical properties and a remarkable capacity for morphological synaptic plasticity. Their large somatic size, their relatively uniform dense clustering in the supraoptic paraventricular nuclei, axon terminals neurohypophysis make them an attractive target direct electrophysiological interrogation. Here, we provide brief review of significant recent findings neuroplasticity neurophysiological these neurones that were presented at symposium "Electrophysiology Magnocellular Neurons" during 13th World Congress on Neurohypophysial Hormones Ein Gedi, Israel April 2019. vasopressin (VP) respond directly to hypertonic stimulation with membrane depolarisation, which is triggered by cell shrinkage-induced opening N-terminal-truncated variant transient receptor potential vanilloid type-1 (TRPV1) channels. New indicate this mechanotransduction depends actin microtubule cytoskeletal networks, coupling TRPV1 channels microtubules responsible mechanical gating Vasopressin also osmostimulation activation epithelial Na+ (ENaC). It was shown recently changes ENaC activity modulate neurone basal firing generating tonic potential. Both oxytocin VP undergo robust excitatory synapse plasticity chronic osmotic stimulation. Recent new glutamate synapses induced salt loading express highly labile Ca2+ -permeable GluA1 receptors requiring continuous dendritic protein synthesis maintenance. Finally, recordings from uniquely tractable neurohypophysial revealed unexpected property activity-dependent neuropeptide release. A fraction voltage-dependent neurosecretion found be independent influx through voltage-gated Together, snapshot advances signalling mechanisms hypothalamic-neurohypophysial system, system continues important contributions field neurophysiology.