Prenylated Phenolic Compounds from the Leaves of Sabia limoniacea and Their Antiviral Activities against Porcine Epidemic Diarrhea Virus

摘要: Porcine epidemic diarrhea virus (PEDV), a serious swine epidemic, has been rampant in Asia since the 1990s. Despite widespread use of PEDV vaccines, occurrence variants requires discovery new substances that inhibit these viruses. During search for inhibitory materials from natural sources, seven sabphenosides (1–7) and flavonoid (8), as well eight known phenolic compounds (9–16), were obtained leaves Sabia limoniacea. The structural determination derivatives (1–8) was accomplished using comprehensive spectroscopic methods. Their absolute configurations assigned by combination ECD exciton chirality method following selective reduction calculation their spectra. bioactivities isolated measured based on abilities to viral replication PEDV. Among test compounds, 15 16 exhibited most promising antiviral activities, with IC50 values 7.5 ± 0.7 μM 8.0 ±...