Performances of NaCS–WSC protein drug microcapsules with different degree of substitution of NaCS using sodium polyphosphate as cross-linking agent
作者： Qing-Xi Wu , Mu-Zhen Li , Shan-Jing Yao
DOI: 10.1007/S10570-014-0209-3
关键词:
摘要: Sodium cellulose sulfate–water soluble chitosan (NaCS–WSC) microcapsules loaded with lactoferrin were fabricated special performances using different degree of substitution (DS) NaCS and WSC as potential micro-drug-carriers for colon. Effect cross-linking agent (sodium polyphosphate) DS on the structures was studied. The results laser scanning confocal microscope showed that fluorescein isothiocyanate-labeled distributed evenly in drug-loaded cross-linker. NaCSs (DS: 0.51 DS: 0.66, respectively) chosen to prepare cross-linker comparison studies. had some effects erosion properties which ratios higher than but no effect swelling behaviors. Drug loading encapsulation efficiencies 0.66) 51.05 ± 0.97 75.88 ± 1.44 %, respectively, 0.51. In vitro release studies percentage drug 0.51) 0.66 simulated colonic fluid (pH 6.4) under mechanism Anomalous (non-Fickian) transport, indicating they are promising candidates sustained protein delivery carriers performances.
springer.com
sci-hub.se 参考文章(55)
U. Schuldt, W. Wagenknecht, A. Richter, Electrosorption of sodium cellulose sulfates with different substitution patterns Cellulose. ,vol. 9, pp. 271- 282 ,(2002) , 10.1023/A:1021168425119
J M Macy, J R Farrand, L Montgomery, Cellulolytic and non-cellulolytic bacteria in rat gastrointestinal tracts. Applied and Environmental Microbiology. ,vol. 44, pp. 1428- 1434 ,(1982) , 10.1128/AEM.44.6.1428-1434.1982
O. Chambin, G. Dupuis, D. Champion, A. Voilley, Y. Pourcelot, Colon-specific drug delivery: Influence of solution reticulation properties upon pectin beads performance International Journal of Pharmaceutics. ,vol. 321, pp. 86- 93 ,(2006) , 10.1016/J.IJPHARM.2006.05.015
Surajit Das, Anumita Chaudhury, Ka-Yun Ng, Preparation and evaluation of zinc–pectin–chitosan composite particles for drug delivery to the colon: Role of chitosan in modifying in vitro and in vivo drug release International Journal of Pharmaceutics. ,vol. 406, pp. 11- 20 ,(2011) , 10.1016/J.IJPHARM.2010.12.015
Yu-Liang Xie, Ming-Jun Wang, Shan-Jing Yao, Preparation and characterization of biocompatible microcapsules of sodium cellulose sulfate/chitosan by means of layer-by-layer self-assembly. Langmuir. ,vol. 25, pp. 8999- 9005 ,(2009) , 10.1021/LA9014338
Qing-Xi Wu, Shan-Jing Yao, Novel NaCS-CS-PPS microcapsules as a potential enzyme-triggered release carrier for highly-loading 5-ASA. Colloids and Surfaces B: Biointerfaces. ,vol. 109, pp. 147- 153 ,(2013) , 10.1016/J.COLSURFB.2013.03.035
C. Mura, A. Nácher, V. Merino, M. Merino-Sanjuán, M. Manconi, G. Loy, A.M. Fadda, O. Díez-Sales, Design, characterization and in vitro evaluation of 5-aminosalicylic acid loaded N-succinyl-chitosan microparticles for colon specific delivery Colloids and Surfaces B: Biointerfaces. ,vol. 94, pp. 199- 205 ,(2012) , 10.1016/J.COLSURFB.2012.01.030
Richard W. Korsmeyer, Robert Gurny, Eric Doelker, Pierre Buri, Nikolaos A. Peppas, Mechanisms of solute release from porous hydrophilic polymers International Journal of Pharmaceutics. ,vol. 15, pp. 25- 35 ,(1983) , 10.1016/0378-5173(83)90064-9
B. Ramaraj, Ganga Radhakrishnan, Hydrogel capsules for sustained drug release Journal of Applied Polymer Science. ,vol. 51, pp. 979- 988 ,(1994) , 10.1002/APP.1994.070510602
A. P. Rokhade, P. V. Kulkarni, N. N. Mallikarjuna, T. M. Aminabhavi, Preparation and characterization of novel semi-interpenetrating polymer network hydrogel microspheres of chitosan and hydroxypropyl cellulose for controlled release of chlorothiazide. Journal of Microencapsulation. ,vol. 26, pp. 27- 36 ,(2009) , 10.1080/02652040802109770