Primary Biliary Cirrhosis and Liver Transplantation

摘要: Primary biliary cirrhosis is a chronic liver disease of unknown cause that predominantly affects middleaged women.1 The syndrome primary arises as consequence nonsuppurative destructive cholangitis involves the septal and larger interlobular bile ducts.2 rate at which bile-duct lesions evolve varies unpredictable. In asymptomatic patients prognosis can be good (two decades), but once have symptoms attributable to disease, its course typically characterized by relentless destruction loss ducts, slowly progressive intrahepatic cholestasis, periportal piecemeal necrosis hepatocytes, hepatic fibroplasia, after few . . .