Behavioral and respiratory characteristics during sleep in neonatal DBA/2J and A/J mice.

摘要: The ventilatory response to hypoxia depends on the carotid body function and sleep-wake states. Therefore, must be measured in a consistent state. In mice, EMG with behavioral indices (coordinated movements, CMs; myoclonic twitches, MTs) has been used assess However, neonatal mice instrumentation could induce stress, altering their behavior ventilation. Accordingly, we examined: (1) if can eliminated for assessing states; (2) characteristics body-mediated respiratory control during sleep (EMG+) or without (EMG-). Seven-day-old DBA/2J A/J were divided into EMG+ EMG- groups. both strains, CMs occurred when was high; MTs present silent/low activity. durations of high activity statistically indifferent. Thus, indicate wake state EMG. stress caused by may distinctively manifested based genetic background. Prolonged agitation observed some (5 13), but not mice. time MT counts indifferent between groups group showed longer less than group. Mean variables (baseline, hyperoxic/hypoxic responses) severely influenced either strain. Individual values more variable Carotid responses (decreased ventilation upon hyperoxia increased mild hypoxia) clearly these instrumentation.