Identity of the α-Chains of the Minor Human Hæmoglobin Components A 2 and A 2 ′ with the α-Chains of Human Hæmoglobin A and F

摘要: THE occurrence of a minor haemoglobin component (A 2′ or B 2), which is related to the well-known fraction A 2, has recently been described1,2. This variant, found in families Negro community James Island, characterized by very low mobility at an alkaline pH. The electrophoretic pattern (at pH 8.8) person heterozygous for this abnormality, shows major (A 0), fast moving (A 1), slow and A 2′ with still lower mobility. A 2 haemoglobin-A 2′ are present equal amounts (0.8–1.2 per cent), sum both being percentage blood normal individual. also demonstrated cases sickle cell trait2, indicating that two abnormalities (‘double spot’ ‘the presence abnormal S’) controlled different pair alleles. In some thalassaemia trait fractions were be increased factor two1,2, ‘double contributed one parent other parent.