Adjunctive treatment in septic shock: What's next?

摘要: Sepsis is a leading cause of death and long-term sequels worldwide. For more than decade, the scientific community providing physicians, patients policy makers with regularly updated guidelines. There some evidence that implementation Surviving Campaign guidelines associated improved outcomes. Though there were major advances in understanding sepsis, management sepsis mainly relies on anti-infective treatments restoration cardiovascular respiratory function according to quantitative protocolized care. Except hormonal interventions such as insulin maintain blood glucose levels less 180mg/dL low doses corticosteroids vasopressin highly selected patients, no adjunct therapy for routine sepsis. Recent years have shown interest revolutionary concepts selective beta-1 receptor antagonists or boost immune system. These provocative approaches yielded promising results various experimental models preliminary data humans. The current narrative review summarized numerous therapies are currently being investigated