Disease Associations: Human Leukocyte Antigen (HLA) and Apolipoprotein E (APOE) Gene
作者： Cornelia M van Duijn
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摘要: The developments of the Human Genome Project have fueled expectations with regard to potential associating variations in genes risk common complex diseases. Despite many problems encountered, examples HLA and apolipoprotein E gene show usefulness this approach. Keywords: association; human leukocyte antigen; apolipoprotein E; disease; polymorphism; complex diseases; genetic epidemiology
sci-hub.se 参考文章(22)
Meredith Wadman, Human Genome Project aims to finish 'working draft' next year. Nature. ,vol. 398, pp. 177- 177 ,(1999) , 10.1038/18250
Neil J. Risch, Searching for genetic determinants in the new millennium Nature. ,vol. 405, pp. 847- 856 ,(2000) , 10.1038/35015718
R. Fears, Building Population Genetics Resources Using the U.K. NHS Science. ,vol. 284, pp. 267- 268 ,(1999) , 10.1126/SCIENCE.284.5412.267
Lindsay A. Farrer, Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease JAMA. ,vol. 278, pp. 1349- 1356 ,(1997) , 10.1001/JAMA.1997.03550160069041
Masaaki Miyata, Jonathan D. Smith, Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nature Genetics. ,vol. 14, pp. 55- 61 ,(1996) , 10.1038/NG0996-55
GJB van Ommen, E Bakker, JT den Dunnen, The human genome project and the future of diagnostics, treatment, and prevention. The Lancet. ,vol. 354, ,(1999) , 10.1016/S0140-6736(99)90241-6
Johanna Kuusisto, Leena Mykkänen, Kari Kervinen, Y. Antero Kesäniemi, Markku Laakso, Apolipoprotein E4 Phenotype Is Not an Important Risk Factor for Coronary Heart Disease or Stroke in Elderly Subjects Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 15, pp. 1280- 1286 ,(1995) , 10.1161/01.ATV.15.9.1280
Neil A. Holtzman, Theresa M. Marteau, Will genetics revolutionize medicine The New England Journal of Medicine. ,vol. 343, pp. 141- 144 ,(2000) , 10.1056/NEJM200007133430213
David N. Cooper, Robert L. Nussbaum, Michael Krawczak, Proposed guidelines for papers describing DNA polymorphism-disease associations. Human Genetics. ,vol. 110, pp. 207- 208 ,(2002) , 10.1007/S00439-001-0672-4
W. J. Strittmatter, A. M. Saunders, D. Schmechel, M. Pericak-Vance, J. Enghild, G. S. Salvesen, A. D. Roses, Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 1977- 1981 ,(1993) , 10.1073/PNAS.90.5.1977