TNFα–308G/A Polymorphism as a Risk Factor for HPV Associated Cervical Cancer in Indian Population
作者： Indu Kohaar , Pushpa Sodhani , Mausumi Bharadwaj , Sudha Salhan , Anita Sharma
DOI: 10.1155/2007/418247
关键词:
摘要: Background: Investigation of the potential association single nucleotide polymorphisms (SNPs) at –308 G/A and –238 Tumor necrosis factor α (TNFα) with susceptibility to HPV-16 associated cervical cancer in Indian women. Methods: The study included 165 histologically confirmed cases 45 precancer 120 patients an equal number (165) healthy controls normal cytology. PCR-RFLP was employed analyze TNFα promoter polymorphisms, which were by direct sequencing. Both screened for Human Papillomavirus (HPV) infection. Results: frequency A allele significantly higher compared control subjects (21% vs. 9% controls; p < 0.01), odds ratio 2.7 (95% CI = 1.41–5.15). Also, women carrying this locus presented 3 times increased HPV 16 infection as evident from carrier genotype distribution between positive (24% 0.01; OR 3.1; 95% 1.60–6.03). No such found TNFα–238 (G/A) polymorphism risk development cancer. Conclusion: It suggests that SNP may represent
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