The allelic distribution of -308 Tumor Necrosis Factor-alpha gene polymorphism in South African women with cervical cancer and control women

摘要: Cervical cancer is due to infection with specific high-risk types of human papillomavirus (HPV). Although the incidence genital HPV in various population groups high, most these regress without intervention. Investigating genetic host factors and cellular immune responses, particularly cytokines, could help understand association between carcinogenesis. The tumor necrosis factor alpha (TNF-α) cytokine plays an important role all stages cervical has ability induce regression tumors. Therefore aim study was investigate allelic distribution -308 TNF-α gene polymorphism South African women compared control women. Included our were histologically proven cervix (n = 244) hospital-based controls 228). All patients from mixed race black Africa. detection a bi-allelic (A/G) promoter region investigated using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) technique. distributions frequencies stratified both into two ethnic groups. In this we observed no risk developing even after combining data populations (X2 2.26). addition, chi-squared test found significant known for allele TNF-α. However, frequency rare high-producing -308A significantly lower when Caucasians Chinese We demonstrated among as notably different Africa other result suggests that disparity may influence levels produced.