Hypothermia ameliorates blast-related lifespan reduction of C. elegans.

摘要: Blast-related mild traumatic brain injury induces significant long-term health issues, yet treatment procedures remain underdeveloped. Therapeutic hypothermia has been postulated as a potentially effective therapy. In Caenorhabditis elegans model, we demonstrate dose-dependent reduction in lifespan following exposure to blast-like shock waves. Using polyvinyl alcohol, show that cavitation is key injurious factor the damaging wave component. Short and long C. mutants demonstrated interaction of genetic environmental longevity-determining factors. Hypothermia reduced term effect exposure. Thus, present an model effects blast-related injury, well evidence merit therapeutic therapy option blast