A novel ring transformation of 5-acylaminouracils and 5-acylamino-pyrimidin-4(3H)-ones into imidazoles
作者： Taisei Ueda , Izumi Matsuura , Nobutoshi Murakami , Shin-ichi Nagai , Jinsaku Sakakibara
DOI: 10.1016/S0040-4039(00)80560-2
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摘要: Abstract 1, 3-Disubstituted 5-acylamino-6-methyluracils (2a-e) were transformed into 2-disubstituted 4-alkylcarbamoyl-5-methyl-1 H -imidazoles (3a-e) by treatment with 5% aqueous sodium hydroxide in ethanol. Similarly, reaction of 5-acylamino-6-methyl-3-phenyl-4-(3 )-pyrimidinones (5a-d) ethanol gave 2-substituted 5-methyl-4-phenylcarbamoyl-1 (6a-d).
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