Safety and efficacy of glucagon as a premedication for upper gastrointestinal endoscopy--a comparative study with butyl scopolamine bromide.

摘要: Background: Glucagon inhibits digestive motility and is used for endoscopic premedication; however, its effect on cardiopulmonary function during endoscopy has not yet been fully investigated. Aim: To clarify the efficacy safety of glucagon compared with butyl scopolamine bromide as upper gastrointestinal premedication. Methods: Two hundred forty consecutive patients over 40 years age, referred endoscopy, without any complications, were studied. These randomly premedicated (SC group) or (G group). Time course changes in blood pressure, arterial oxygen saturation, heart rate number retching episodes examined. The glucose tablets after to prevent hypoglycaemia caused by was evaluated. Cardiopulmonary parameters also examined 77 complicated premedication (GC group). Results: A continuous increase observed SC group, but G GC groups. Blood saturation different between Hypoglycaemia-related symptoms frequent group tablets, prevented administration glucose. Conclusions: Glucagon a weaker than bromide. Glucose prevents hypoglycaemia-related glucagon.