Highly Prolific Booroola Sheep Have a Mutation in the Intracellular Kinase Domain of Bone Morphogenetic Protein IB Receptor (ALK-6) That Is Expressed in Both Oocytes and Granulosa Cells
作者： Theresa Wilson , Xi-Yang Wu , Jennifer L. Juengel , Ian K. Ross , Joanne M. Lumsden
DOI: 10.1095/BIOLREPROD64.4.1225
关键词:
摘要: The Booroola fecundity gene (FecB) increases ovulation rate and litter size in sheep is inherited as a single autosomal locus. effect of FecB additive for (increasing by about 1.6 corpora lutea per cycle each copy) has been mapped to chromosome 6q23-31, which syntenic human 4q21-25. Bone morphogenetic protein IB (BMP-IB) receptor (also known ALK-6), binds members the transforming growth factor-beta (TGF-beta) superfamily, located region containing have mutation (Q249R) highly conserved intracellular kinase signaling domain BMP-IB receptor. segregated with phenotype backcross half-sib flocks no recombinants. was not found individuals from number breeds derived strain. BMPR-IB expressed ovary situ hybridization revealed its specific location oocyte granulosa cell. Expression mRNA encoding BMP type II widespread throughout ovary. second reported defect TGF-beta pathway affecting fertility following recent discovery mutations factor, GDF9b/BMP15.
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