Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma
作者： Sabine Mazerbourg
DOI: 10.1007/978-1-59745-292-2_27
关键词: Biology 、 Granulosa cell proliferation 、 Internal medicine 、 Growth differentiation factor 、 Bone morphogenetic protein 7 、 Granulosa cell 、 Bone morphogenetic protein 、 Paracrine signalling 、 Cell biology 、 Endocrinology 、 Bone morphogenetic protein 2 、 Bone morphogenetic protein 15
摘要: The ligands of the transforming growth factor β (TGF-β) superfamily are important paracrine/autocrine regulators ovarian follicular development. This group includes TGF-β. activins, bone morphogenetic proteins (BMPs), differentiation factors (GDFs), and others. Nine BMPs GDFs expressed in ovary, with a well-conserved pattern expression among mammalian species. Oocytes express BMP6, BMP15, GDF9: theca cells BMP3, BMP3b, BMP4, BMP7; granulosa BMP2 BMP5. In vivo studies have revealed importance GDF9 BMP15 control early ovulation. vitro, most induce cell proliferation but reduce follicle stimulating hormone (FSH)-induced progesterone production, thus delaying process.
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