Prophylaxis of infection in bone marrow transplants.

摘要: Bone marrow transplants experience severe immuno-deficiency as a consequence of pretransplant radiation and chemotherapy, transient granulocytopenia before engraftment, post-transplant prevention treatment graft-versus-host disease with immuno-suppressive agents. During periods granulocytopenia, chemoprophylaxis the oral fluorinated quinolones can prevent colonization infection gram-negative bacilli, is better tolerated than non-absorbable antibiotics or trimethoprim-sulfamethoxazole more cost-effective laminar-air-flow isolation prophylactic granulocyte transfusions. Antifungal prophylaxis nystatin, ketoconazole amphotericin B, however, has not been consistently effective; empiric intravenous B therapy still most reliable way to fatal fungal infections. Following cytomegalovirus interstitial pneumonia be prevented in cytomegalovirus-seronegative patients by use blood products immune globulin. In cytomegalovirus-seropositive patients, DHPG (ganciclovir) currently being evaluated controlled clinical trial. Herpes simplex varicella-zoster infections treated effectively acyclovir, but routine acyclovir cost-effective. Trimethoprim-sulfamethoxazole used for Pneumocystis carinii may continued chronic late bacterial