Streptococcus mitis sepsis in bone marrow transplant patients receiving oral antimicrobial prophylaxis

摘要: Abstract purpose: Streptococcal infection has increasingly become a problem in neutropenic patients. We report on an outbreak of Streptococcus mitis sepsis six bone marrow transplant patients receiving oral antimicrobial prophylaxis. and methods: performed epidemiologic study all our program from 1986 to 1988. The hospital microbiology records for were reviewed. All treated according specified protocols, including prophylactic regimen that was changed late 1987 vancomycin/polymyxin/tobramycin norfloxacin. Identification, susceptibility testing, whole cell protein analysis streptococcal isolates at the Reference Antimicrobial Investigations Laboratories Centers Disease Control. results: detected cases S. among 21 undergoing transplantation. No other concurrent pathogen isolated any patient time bacteremia. Bacteremia developed within 72 hours five associated with severe mucositis four An environmental failed reveal common source outbreak, revealed each be distinct. Of 12 vancomycin/polymyxin/tobramycin, one bacteremia, versus nine norfloxacin (p conclusion: believe bacteremia is potential complication transplantation prophylaxis norfloxacin, especially setting mucositis.