Hydrogel containing dexamethasone-loaded nanocapsules for cutaneous administration: preparation, characterization, and in vitro drug release study.
作者： M.L. Marchiori , G. Lubini , G. Dalla Nora , R.B. Friedrich , M.C. Fontana
DOI: 10.3109/03639041003598960
关键词:
摘要: Context: Our group previously reported the development of dexamethasone-loaded polymeric nanocapsules as an alternative for topical dermatological treatments. Objective: study aimed to prepare and characterize a hydrogel containing this system improve effectiveness glucocorticoid cutaneous disorders. Methods: For antiproliferative activity assay, dexamethasone solution D-NC were tested on Allium cepa root meristem model. prepared by interfacial deposition preformed polymer. Hydrogels using Carbopol Ultrez® 10 NF, polymer, characterized according following characteristics: pH, drug content, spreadability, viscosity, in vitro release. Results Discussion: Nanocapsules showed mean particle size zeta potential 201 ± 6 −5.73 0.42 nm, respectively. They demonstrated lower mitotic index (4.62%) compared free (8.60%). Semisolid formulations presented acidic pH values adequate content (...
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