Tumour necrosis factor alpha inhibitor therapy and rehabilitation for the treatment of ankylosing spondylitis: a systematic review.

摘要: Abstract Objectives To systematically review the evidence for a synergistic effect of combining rehabilitation with biological anti-tumour necrosis factor (TNF) therapy in patients ankylosing spondylitis (AS). Methods Data were analysed to identify most effective programmes, best endpoints effectiveness, and patient subgroups likely benefit from combination therapy. Systematic MEDLINE Embase searches performed studies evaluating programmes AS. Evidence was categorised by study type, efficacy, adverse effects other outcomes summarised. Results Of 75 identified, 13 investigated programme TNF inhibitor therapy, while remainder studied standard (often not specified). these few suggest that combined plus anti-TNF is more terms symptom severity, disease activity, disability quality-of-life indices versus biologic alone or medical or, non-comparative studies, compared baseline. The appears be supervised in-patient an educational component. Available data do provide guidance on appropriate Combined, appear have effect, possibly due increased adherence exercise. Exercise regimes are if include education Conclusions Further randomized, controlled trials comparing investigating longer-term benefits inhibitors different AS needed.