The therapeutic potential of centrally acting dopamine agonists

摘要: Much interest has been stimulated by epidemiological evidence which suggests that abortion, foetal abnormality, haemo- poietic disorders and neuropathy occur- ring in operating theatre staff might be due to chronic exposure waste anaes- thetic gases. The interaction of nitrous oxide vitamin B~2 can explain each these disorders. In contrast, there is no theoretical or experimental basis for believing they could caused trace concentrations halothane other currently used volatile anaesthetic agents. lowest level at shown cause signifi- cant inhibition methionine synthase 1 000 p.p.m. 9 also the concentration foetotoxicity observed rodents. 450 p.p.m, highest demonstrated without effect on hepatic meth- ionine activity rats dur- ing prolonged 9. Comparable measurements cannot easily made man but data from suggest maximum safe lies between allowance a two-fold safety mar- gin would then 200 should safe. Levels excess com- monly occur unscavenged theatres Bl2 pro~4des an unanswerable case scavenging gases any area aaaesthetics are administered. 25 certainly attained with use cuffed tracheal tube efficient system.