Hyperbaric oxygen therapy modulates serum OPG/RANKL in femoral head necrosis patients.
作者： Giuliano Vezzani , Silvia Quartesan , Pasqua Cancellara , Enrico Camporesi , Devanand Mangar
DOI: 10.1080/14756366.2017.1302440
关键词:
摘要: Hyperbaric oxygen therapy (HBOT) has beneficial effects on avascular necrosis of femoral head (ANFH), but its mechanism action is still unclear. We investigated if HBOT upregulates serum osteoprotegerin (OPG) and/or inhibits osteoclast activation. 23 patients with unilateral ANFH at stage I, II and III consented to the study: received standard HBOT. Serum OPG levels were obtained beginning (T0), after 15 sessions (T1), 30 (T2), a 30-day break (T3), 60 (T4). Magnetic resonance imaging (MRI) was T0 about one year from end HBO treatments. Lesion size compared between pre- post-HBOT. 19 completed study. reduced pain symptoms in all patients. significantly lesion I 2 11 increased receptor activator nuclear factor kappa-B ligand (RANKL) did not change.
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