The influence of acute-phase levels of haemostatic factors on reperfusion and mortality in patients with acute myocardial infarction treated with streptokinase

摘要: Background The fibrinolytic system and von Willebrand factor (vWF) have been shown to play a role as risk factors for myocardial infarction. We performed this prospective cohort study determine if components in the or vWF before during treatment of AMI with streptokinase (SK) could predict reperfusion, recurrent ischaemia, reinfarction mortality at one year, five years. Reperfusion ischaemia were assessed by continuous vectorcardiography. setting was Umea university hospital Skelleftea county hospital, Sweden. Results 139 patients included; successful reperfusion obtained 53%. tPA activity, PAI-activity, PAI-mass concentration analysed immediately on arrival after 4 10 h. High measured activity > 25 U/L start treatment, associated reperfusion. No significant associations between pre-treatment levels variables found. Elevated PAI-1 mass SK higher death but not worse prognosis when corrected age. Conclusion Pre-treatment PAI-1, showed no association ischaemia. prognosis.