Why is there a change in patterns of GE cancer

摘要: Recent decades have seen a worrying trend in incidence rates of distal oesophageal and proximal gastric cancers. Fuelled by radical changes lifestyle, diet, physical activity environmental exposures, as well an ageing population host genetic predisposition, the adenocarcinoma (OAC) is on rise Western populations. While overall cancers declining, society means that increase absolute numbers expected over coming years. Both tend to present at advanced stage, hence prognosis remains poor despite increasingly effective screening treatment strategies. The development malignancies influenced myriad factors, not least geographical, racial socioeconomic differences addition lifestyle choices. multidimensional nature these risk factors requires holistic understanding their net influence malignancy. This review explores evidence base for established putative It hoped with clear important multidisciplinary approach including primary prevention, regular high-risk groups continued research into molecular biology gastrointestinal carcinogenesis may facilitate reduction rates, early detection optimal management upper malignancies.