Asymmetric Guerbet Reaction to Access Chiral Alcohols.
作者： Kun Wang , Lin Zhang , Weijun Tang , Huaming Sun , Dong Xue
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摘要: The first example of an asymmetric Guerbet reaction has been developed. Using commercially available, classic Noyori RuII -diamine-diphosphine catalysts, well-known in hydrogenation, racemic secondary alcohols are shown to couple with primary the presence a base, affording new chiral enantiomeric ratios up 99:1. Requiring no reducing agents, protocol provides easy, alternative route for synthesis alcohols. Mechanistic studies reveal that proceeds via Ru-catalyzed hydrogen autotransfer process concert base-promoted allylic alcohol isomerization.
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