A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues

摘要: The closely linked IGF2 and H19 genes on human chromosome 11p15.5 are monoallelically expressed as a result of genomic imprinting show altered expression in Wilms' tumors (WTs). To map regional we have sought to isolate additional close IGF2/H19 characterize their allelic patterns. Here report novel gene, provisionally named L23MRP [L23 (mitochondrial)-related protein], which is oriented 'tail-to-tail' with transcribed within 40 kb the last exon. biallelically many mid-fetal adult tissues. This gene also at normal levels WTs lost either via loss maternal or an epigenetic pathway involving site-specific DNA hypermethylation. These data indicate that, least post-embryonic stages, functionally insulated from imprinted domain.