Genomic Imprinting of a Human Apoptosis Gene Homologue, TSSC3
作者： Andrew P. Feinberg , Maxwell P. Lee
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摘要: Genomic imprinting is an epigenetic modification of the gamete or zygote leading to parental origin-specific gene expression in somatic cells offspring. We have previously identified a cluster imprinted genes on human chromosome 11p15.5, region involved Beckwith-Wiedemann syndrome, Wilms' tumor, and ovarian, breast, lung cancer. Here we show that TSSC3, which homologous mouse apoptosis TDAG51 maps this region, expressed from maternal allele normal development. This result important for three reasons: (a) TSSC3 first apoptosis-related any species found be imprinted; (b) it located within tumor suppressor 11p15; (c) lies 15 kb nonimprinted hNAP2, thus defining small boundary interval between 11p.
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