MicroRNA-driven deregulation of cytokine expression helps development of drug resistance in metastatic melanoma

摘要: microRNAs are major components of the eukaryotic post-transcriptional machinery and frequently deregulated during cancer development. Increasing evidence points to them also as key players in establishment drug resistance. In this review, we provide an updated overview role miRNAs melanoma development resistance postulate that they able drive these processes concert with deregulation inflammatory angiogenic cytokine expression. Notably, have identified by querying Cancer Genome Atlas database, a defined set which mostly impact on recognized main downstream pathways controlled them. Most importantly, miRNAs, down-regulated metastatic melanomas compared primary tumors, predict prognosis BRAF-mutated patients. Finally, discuss possibility common miRNA signature characterizes not only acquired MAPKi but innate anti-PD-1 immunotherapy, since conditions both associated alterations same pro-angiogenetic pro-inflammatory pathways.