Increased insulin sensitivity and fibrinolytic capacity after dietary intervention in obese women with polycystic ovary syndrome

摘要: In overweight women with polycystic ovary syndrome (PCOS), increased insulin resistance has been observed. Since abdominal obesity is associated impaired fibrinolytic capacity and elevated levels of plasminogen activator inhibitor (PAI-1) since PAI-1 seems to be related resistance, we investigated the possible effects dietary intervention on lipids, fibrinolysis, coagulation, sensitivity in obese PCOS women. Nine aged 22 39 years (median weight, 97 kg) ate a protein-rich very—low-calorie diet (VLCD) (Nutrilett, Nycomed Pharma, Oslo, Norway; 421 kcal/d) for 4 weeks (part 1). After significant reductions body fat (13%, P < .01), two nine achieved regular menstruation became pregnant. Six remaining continued conventional low-calorie (1,000 1,500 next 20 2), during which time they were generally able preserve loss obtained part 1 study. During 1, total serum cholesterol (29%, = .001) fasting triglyceride ([TG] 31%, .05) observed, as well glucose (6%, (20%, .05). Insulin (glucose disposal rate [GDR]) was by 93% (P finishing 2, still significantly (86%, activity reduced (54%, Moreover, overall improved (serum d-dimer concentration 75%, conclusion, through intensive adequate weight it change an unfavorable atherothrombogenic risk profile (PCOS) Most convincingly,