A reassessment of the neurotoxicity of pyrethroid insecticides.

摘要: The pyrethroids are a widely used class of insecticides to which there is significant human exposure. They however generally regarded as safe man, and have been few reports fatalities. Their acute toxicity dominated by pharmacological actions upon the central nervous system (CNS), predominantly mediated prolongation kinetics voltage-gated sodium channels, although other mechanisms operate. This review summarizes our present understanding such options antagonize them. One problem very clear heterogeneity pyrethroid sensitivity that seen across channel subtypes; however, distribution function these poorly characterized. also provides an overview recent studies suggest additional effects pyrethroids: developmental neurotoxicity, production neuronal death, action via metabolites. evidence for at equivocal, but all 3 carry important implications health.