Conformational Switch and Structural Basis for Oncogenic Mutations of Ras Proteins
作者： S.-H. Kim , G. G. Privé , M. V. Milburn
DOI: 10.1007/978-3-642-78267-1_13
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摘要: Ras proteins play an important role in the signaling of cell growth and differentiation. Mammalian ras are made up 188 or 189 amino acids with approximate molecular mass 21 kDa, hence named p21. Three genes have been identified human cells, H-ras, K-ras, N-ras, they all show a high degree sequence homology for first 165 acids, after which sequences diverge. The p21 attached to cytoplasmic side membrane through polyisoprenoid group is covalently linked Cys-186 (Hancock et al. 1989; Buss Schafer 1989) possess inherent GTPase activity that stimulated by activating protein (GAP; Trahey McCormick 1987; Vogel 1988; 1988) neurofibromatosis type 1 NF1 (Martin 1990; Xu 1990).
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sci-hub.st 参考文章(38)
Channing J. Der, The ras family of oncogenes. Cancer treatment and research. ,vol. 47, pp. 73- 119 ,(1989) , 10.1007/978-1-4613-1599-5_4
AC Verrotti, JB Crechet, F Di Blasi, G Seidita, MG Mirisola, C Kavounis, V Nastopoulos, E Burderi, E De Vendittis, A Parmeggiani, O Fasano, RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP. The EMBO Journal. ,vol. 11, pp. 2855- 2862 ,(1992) , 10.1002/J.1460-2075.1992.TB05353.X
J John, M Frech, A Wittinghofer, Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction. Journal of Biological Chemistry. ,vol. 263, pp. 11792- 11799 ,(1988) , 10.1016/S0021-9258(18)37854-2
J Feuerstein, R S Goody, M R Webb, The mechanism of guanosine nucleotide hydrolysis by p21 c-Ha-ras. The stereochemical course of the GTPase reaction. Journal of Biological Chemistry. ,vol. 264, pp. 6188- 6190 ,(1989) , 10.1016/S0021-9258(18)83331-2
L A Feig, G M Cooper, Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins. Molecular and Cellular Biology. ,vol. 8, pp. 2472- 2478 ,(1988) , 10.1128/MCB.8.6.2472
S Hattori, D J Clanton, T Satoh, S Nakamura, Y Kaziro, M Kawakita, T Y Shih, Neutralizing monoclonal antibody against ras oncogene product p21 which impairs guanine nucleotide exchange. Molecular and Cellular Biology. ,vol. 7, pp. 1999- 2002 ,(1987) , 10.1128/MCB.7.5.1999
Henry R. Bourne, David A. Sanders, Frank McCormick, The GTPase superfamily: conserved structure and molecular mechanism Nature. ,vol. 349, pp. 117- 127 ,(1991) , 10.1038/349117A0
J. Buss, P. Solski, J. Schaeffer, M. MacDonald, C. Der, Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal. Science. ,vol. 243, pp. 1600- 1603 ,(1989) , 10.1126/SCIENCE.2648572
Peter H. Seeburg, Wendy W. Colby, Daniel J. Capon, David V. Goeddel, Arthur D. Levinson, Biological properties of human c-Ha-ras1 genes mutated at codon 12 Nature. ,vol. 312, pp. 71- 75 ,(1984) , 10.1038/312071A0
Meg Trahey, Gail Wong, Robert Halenbeck, Bonnee Rubinfeld, George A Martin, Martha Ladner, Christopher M Long, Walter J Crosier, Ken Watt, Kirston Koths, Frank McCormick, Molecular cloning of two types of GAP complementary DNA from human placenta Science. ,vol. 242, pp. 1697- 1700 ,(1988) , 10.1126/SCIENCE.3201259