Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics

摘要: Organic cations (OCs) constitute a diverse array of compounds physiological, pharmacological, and toxicological importance. Renal secretion these compounds, which occurs principally along the proximal portion nephron, plays critical role in regulating concentration OCs plasma clearing body potentially toxic xenobiotic OCs. Transepithelial OC transport kidney involves separate entry exit steps at basolateral luminal aspects renal tubular cells. It is increasingly apparent that reflects concerted activity suite processes arranged parallel each pole tubule Most transporters appear to dominate belong single family proteins: OCT Family. The characterization their activity, localization within distinct regions kidney, has permitted development models describing molecular cellular basis