C-type particles are inducible in Se-Ax, a continuous T-cell line from a patient with Sézary's syndrome.

摘要: Se-Ax is a continuous mature T-cell line that we have established from patient with Sezary's syndrome. An important finding was the cell required human serum for initial growth. Here show transfer of permanent to medium deficient induces production C-type retroviral-like particles unique morphology. Ultrastructurally, these are 120 nm in diameter hexagonal shape, and small, centrally located round core 30 nm. They observed only extra-cellularly; typical budding, however, not found. Both by serological testing molecular analysis substantiate morphological conclusion do represent common or animal retroviruses. The inducibility may be hint as possible endogenous origin.