SARS-CoV-2 dysregulation of PTBP1 and YWHAE/Z gene expression: A primer of neurodegeneration
DOI: 10.1016/J.MEHY.2020.110212
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摘要: SARS-CoV-2 neurotropism has been increasingly recognized by its imaging and syndromic manifestations in the literature. The purpose of this report is to explore limited yet salient current evidence that SARS-CoV-2's host genomic targets PTBP1 14-3-3 protein isoform encoding genes YWHAE YWHAZ may be hold key understanding how triggers neurodegeneration it contribute onset neurodegenerative disease. Considering silencing particular recently shown reverse clinical parkinsonism induce neurogenesis, as well known interactions YWHAE/Z with coronaviruses - most notably SARS-CoV, recent studies reinvigorate infectious etiology hypotheses on major disease such AD iPD. human definite have achieve long-term latency within mammalian CNS a result specific accommodating mutations, corroboration genomic-level neuroimaging vast potential implications for
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