Neurology of anomia in the semantic variant of primary progressive aphasia

摘要: The semantic variant of primary progressive aphasia (PPA) is characterized by the combination word comprehension deficits, fluent and a particularly severe anomia. In this study, two novel tasks were used to explore factors contributing single most common factor was blurring distinctions among members category, leading errors overgeneralization in word–object matching as well definitions object descriptions. This more pronounced for natural kinds than artifacts. patients with anomias, conceptual maps extensively disrupted so that inter-category impaired intra-category distinctions. Many objects could not be named aloud matched correct mild but anomia, reflecting gradual intensification naming disorder becomes severe. Accurate descriptions frequent accurate all experienced prominent deficits interfered everyday activities no consequential impairment usage or face recognition. Magnetic resonance imaging revealed three characteristics: greater atrophy left hemisphere; anterior components perisylvian language network superior middle temporal gyri; recognition inferior medial lobes. sided asymmetry extension explains profound provides anatomical basis distinguishing from partially overlapping group fulfil widely accepted diagnostic criteria dementia.