Abnormal monoclonal antibody-defined helper/suppressor T-cell subpopulations in multiple myeloma: relationship to treatment and clinical stage.
作者： K. H. G. Mills , J. C. Cawley
DOI: 10.1111/J.1365-2141.1983.TB02021.X
关键词:
摘要: Among peripheral blood T cells from 25 patients with myeloma, % OKT8+ suppressor were increased in all but two (mean 63 +/- 12%; normal 34 8%), present absolute numbers 0.5 0.3 x 10(9)/l; range 0.2-0.6 10(9)/l). OKT4+ helper reduced relative and 40 12%, 0.2 64 8%, 0.6-1.4 Similar results obtained treated untreated cases, of different clinical stage. In the 12 tested, gamma Fc-rosetting 28 10%; 10%). four IgM disease, similar, less marked, changes monoclonal antibody-defined T-cell subsets observed. The findings are discussed relation to those other B-cell malignancies, it is suggested that imbalances helper/OKT8+ may be important immune suppression many these disorders.
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