Comparative analgesic efficacy of nimesulide and diclofenac gels after topical application on the skin.

摘要: Nimesulide is a newer non-steroidal anti-inflammatory drug (NSAID) with selective cyclo-oxygenase (COX)-2 blocking property and has demonstrated potent analgesic activity on oral rectal administration. However, the Cmax through both these routes reached only after 3 h of Dose-dependent gastrointestinal side effects also limit concentration that can be achieved at site inflammation when administered routes. The present study was conducted to evaluate antinociception induced by new gel formulation nimesulide applied skin. Efficacy topical 1% (w/w) studied mice in acetic-acid-induced writhing, tail flick latency (TFL) test formalin-induced pain models. antinociceptive effect compared diclofenac (1% w/w). Both drugs dose-dependent analgesia peak seen between 90 120 min treatment. Greater (expressed as percent maximum possible effect) writhing than TFL test, indicating peripheral action drugs. evidenced significant protection first phase modulation nociceptors unlike other conventional NSAIDs. This suggests COX-2 may primary contributor afferent evoked increase prostanoid-mediated changes processing. Antinociception following application skin lower intraperitoneal administration, localised application. findings suggest transgel provides topically.